Triumph of Experimental Technique over the Secretiveness of Nature
from Atlas of Protein Sequence and Structure 1965

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This Atlas voluminously illustrates the triumph of experimental technique over the secretiveness of nature.  Perhaps nowhere has the power of the scientific method been more brilliantly demonstrated than in the development of procedures for the study of the chemistry of life.  As recently as twenty years ago, it was customary for biologists to have a hopeless attitude about biochemistry.  Some details might be elicited, perhaps, but living things were thought to be so very complex and intricate that there surely was no hope of fully “understanding” them in all their chemical detail.  Who, if he really comprehended the difficulty of the problem, would dare to think of man’s ever knowing the detailed structure of a protein, for example, much less be able to synthesize it?  Who would ever understand the mechanism of an enzyme as clearly as a chemist understands the details of an inorganic reaction?  How could we ever hope to know the atomic details of a protein crystal?

Today some of these ambitions have already been attained, and the others no longer seem out of reach.  We now rationally hope to be able to discover and understand the finest chemical details of living processes.  These accomplishments have been made possible by the combined effect of several new approaches.
 Darwin and Atlas

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